MSM is used for chronic pain, osteoarthritis, joint inflammation, rheumatoid arthritis, osteoporosis, bursitis, tendinitis, tenosynovitis, musculoskeletal pain, muscle cramps, scleroderma, scar tissue, stretch marks, alopecia (hair loss), wrinkles, protection against sun/wind burn, eye inflammation, oral hygiene, periodontal disease, wounds, cuts, and abrasions. Orally, MSM is also used for relief of allergies (allergic rhinitis, allergic sinusitis, allergy-induced asthma, inhalant allergens, environmental allergens), drug hypersensitivity, gastrointestinal upset, chronic constipation, gastric hyperacidity, ulcers, diverticulosis, premenstrual syndrome (PMS), mood elevation, obesity, poor circulation, hypertension, and elevated serum cholesterol. It is also used orally for diabetes mellitus type 2, interstitial cystitis, hepatic dysfunction, Alzheimer’s disease, snoring, lung dysfunction including emphysema and pneumonia, chronic fatigue syndrome, autoimmune disorders (systemic lupus erythematous), HIV infection and AIDS, and cancer (breast cancer and colon cancer). Other oral uses of MSM include eye inflammation, mucous membrane inflammation, myositis ossificans generalis, temporomandibular joint dysfunction, leg cramps, connective tissue disorders, migraine, headaches, hangover, parasitic infections of the intestinal and urogenital tracts including Trichomonas vaginalis and Giardia, Candida albicans and other yeast infections, insect bites, radiation poisoning, and as an immunostimulant.