Melatonin is used for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind, and benzodiazepine and nicotine withdrawal. Melatonin is also used orally for Alzheimer’s disease, tinnitus, depression, delayed sleep phase syndrome (DSPS), chronic fatigue syndrome (CFS), fibromyalgia, migraine and cluster headaches, idiopathic stabbing headache, and insomnia associated with attention deficit-hyperactivity disorder (ADHD), and irritable bowel syndrome (IBS). Other uses include hypertension, hyperpigmentation, osteoporosis, breast cancer, brain cancer, lung cancer, prostate cancer, head cancer, neck cancer, and gastrointestinal cancer. It is also used for thrombocytopenia, cachexia, neuropathy, and asthenia associated with cancer chemotherapy. Melatonin is also used orally for epilepsy, as an anti-aging agent, and for menopause.