Manganese is used for prevention and treatment of manganese deficiency, osteoporosis, epilepsy, microcytic anemia, and symptoms of premenstrual syndrome (PMS). Manganese is a powerful antioxidant and controls the metabolism of many nutrients. Without manganese, the body is unable to properly break down carbohydrates, amino acids, and cholesterol. Manganese is also essential to making urine, sugar, and the neurotransmitter GABA. In combination, manganese is used with chondroitin sulfate and glucosamine hydrochloride for osteoarthritis.