Arginine is used for cardiovascular conditions including congestive heart failure (CHF), angina pectoris, hypertension, and coronary artery disease. L-arginine is also used for intermittent claudication, senile dementia, erectile dysfunction, and male infertility. Furthermore, L-arginine is used for prevention of the common cold, interstitial cystitis, cyclosporine nephrotoxicity, pre-eclampsia, improving athletic performance, improving immune function, and preventing necrotizing enterocolitis in premature infants. In combination with ibuprofen, L-arginine is used orally for migraine headaches, and as an adjunct to chemotherapy in breast cancer. In combination with hydroxymethylbutyrate (HMB) and glutamine, L-arginine is used orally for treating weight loss in people with AIDS. In the perioperative period, to reduce infections, improve wound healing, and shorten recovery time, L-arginine is used orally in combination with RNA and EPA.