Grape seed is used for preventing cardiovascular disease, varicose veins, hemorrhoids, atherosclerosis, hypertension, peripheral vascular disease, edema associated with injury or surgery, and myocardial or cerebral infarction. Grape is also used and as a mild laxative for constipation. Grape seed is used for diabetes complications such as neuropathy or retinopathy, improving wound healing, aging skin, preventing dental caries, cancer prevention, age-related macular degeneration (ARMD), poor night vision, liver cirrhosis, allergic rhinitis, and prevention of collagen breakdown.