Glutamine is used for depression, moodiness, irritability, anxiety, insomnia, short bowel syndrome, Crohn’s disease, and enhancing exercise performance. Glutamine is also used orally for HIV wasting, abnormal intestinal permeability in people with HIV, chemotherapy-induced mucositis, chemotherapy-induced diarrhea, chemotherapy-induced neuropathy, and protection of immune and gut barrier function in people with esophageal cancer undergoing radiochemotherapy. It is also used for attention deficit-hyperactivity disorder (ADHD), cystinuria, peptic ulcer, ulcerative colitis, sickle cell anemia, improving recovery after bone marrow transplant, and for alcohol withdrawal support. It is also used orally as parenteral nutrition, for preventing morbidity in trauma patients, preventing infectious complications in critically ill patients, and for paclitaxel-induced myalgia and arthralgia.