Folate (L-Methylfolate):Folate is in the B vitamin family. Many people have a genetic mutation called the MTHFR polymorphism. These individuals have a very limited ability to breakdown and process Folic Acid.Folate aids in protein metabolism and promoting red blood cell formation. Folate may also play a role in controlling homocysteine levels, thus reducing the risk for coronary heart disease. Folate deficiency affects cell growth and protein production.Folate is used for preventing and treating megaloblastic anemia resulting from folate or vitamin B12 deficiency, megaloblastic anemia in sickle cell disease, and for folate deficiency in intestinal malabsorption or sprue. It is also used for preventing neural tube defects, reducing the risk of colorectal cancer. In addition Folate is used for hyperhomocysteinemia, coronary artery disease, fragile-X syndrome, gingival hyperplasia, memory deficit, Alzheimer’s disease, age-related hearing loss, age-related macular degeneration (AMD), vitiligo, osteoporosis, restless leg syndrome, insomnia, depression, peripheral neuropathy, myelopathy, and AIDS. It is also used for reducing lometrexol and methotrexate toxicity and for preventing signs of aging, heart attack, and stroke. Folate is also used for other conditions commonly associated with folate deficiency, including ulcerative colitis, liver disease, alcoholism, renal dialysis, and drug-induced deficiency related to phenytoin, primidone, barbituratesand nitrofurantoin.