Bromelain is used for acute postoperative and post-traumatic conditions of swelling, especially of the nasal and para-nasal sinuses. It is also used orally for burn debridement, anti-inflammatory action, allergic rhinitis, prevention of epinephrine-induced pulmonary edema, smooth muscle relaxation, stimulation of muscle contractions, inhibition of blood platelet aggregation, enhanced antibiotic absorption, cancer prevention, shortening of labor, and enhanced excretion of fat. Bromelain is also used orally for mild ulcerative colitis.
In combination with trypsin and rutin, bromelain is used orally for osteoarthritis.